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Title: Development and optimization of micro/nanoporous osmotic pump tablets
Authors: Siracha Tuntikulwattana
Ampol Mitrevej
Teerakiat Kerdcharoen
Desmond B. Williams
Nuttanan Sinchaipanid
Mahidol University
University of South Australia
Keywords: Agricultural and Biological Sciences;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jun-2010
Citation: AAPS PharmSciTech. Vol.11, No.2 (2010), 924-935
Abstract: Micro/nanoporous osmotic pump tablets coated with cellulose acetate containing polyvinylpyrolidone (PVP) as pore formers were fabricated. Propranolol hydrochloride was used as a model drug in this study. Formulation optimization based on USP 31 requirements was conducted following a central composite design using a two-level factorial plan involving two membrane variables (pore former and coating levels). Effect of molecular weight of pore former (PVP K30 and PVP K90) was also evaluated. Responses of drug release to the variables were analyzed using statistical software (MINITAB 14). Scanning electron microscopy and atomic force microscopy showed that the pores formed by PVP. The drug release was dependent on the molecular weight and concentration of PVP and the level of coating. The results showed that acceptable 12-h profile could be achieved with only specific range of PVP K30-containing membrane at the defined membrane thickness. However, satisfactory 24-h profile could be accomplished by both PVP K30 and PVP K90-containing membrane at the range and membrane thickness tested. Preparation and testing of the optimized formulation showed a good correlation between predicted and observed values. © 2010 American Association of Pharmaceutical Scientists.
ISSN: 15309932
Appears in Collections:Scopus 2006-2010

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