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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/28540
Title: Genome-wide association study reveals multiple loci associated with primary tooth development during infancy
Authors: Demetris Pillas
Clive J. Hoggart
David M. Evans
Paul F. O'Reilly
Kirsi Sipilä
Raija Lähdesmäki
Iona Y. Millwood
Marika Kaakinen
Gopalakrishnan Netuveli
David Blane
Pimphen Charoen
Ulla Sovio
Anneli Pouta
Nelson Freimer
Anna Liisa Hartikainen
Jaana Laitinen
Sarianna Vaara
Beate Glaser
Peter Crawford
Nicholas J. Timpson
Susan M. Ring
Guohong Deng
Weihua Zhang
Mark I. McCarthy
Panos Deloukas
Leena Peltonen
Paul Elliott
Lachlan J.M. Coin
George Davey Smith
Marjo Riitta Jarvelin
Imperial College London
International Centre for Life
UCL Institute of Child Health
University of Bristol
Oulun Yliopisto
Oulu University Hospital
University of Oxford
Mahidol University
National Institutes of Health, Bethesda
Jane & Terry Semel Institute for Neuroscience & Human Behavior
University of California, Los Angeles
Tyoterveyslaitos
Wellcome Trust Centre for Human Genetics
Wellcome Trust Sanger Institute
Institute for Molecular Medicine Finland (FIMM)
Helsingin Yliopisto
National Institute for Health and Welfare
Medical Research Council
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Feb-2010
Citation: PLoS Genetics. Vol.6, No.2 (2010)
Abstract: Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P<5×10-8, and 5 with suggestive association (P<5×10-6). The loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3). Genes at four of the identified loci are implicated in the development of cancer. A variant within the HOXB gene cluster associated with occlusion defects requiring orthodontic treatment by age 31 years. © 2010 Pillas et al.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77649210349&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/28540
ISSN: 15537404
15537390
Appears in Collections:Scopus 2006-2010

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