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Title: Acute radiation dermatitis in breast cancer: Topical therapy with vitamin E acetate in lipophilic gel base
Authors: S. Martella
M. Rietjens
V. Lohsiriwat
R. Lazzari
A. Vavassori
B. A. Jereczek
V. Lazzati
M. C. Leonardi
J. Y. Petit
Istituto Europeo di Oncologia
Mahidol University
Universita degli Studi di Milano
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 23-Dec-2010
Citation: ecancermedicalscience. Vol.4, No.1 (2010)
Abstract: Background: Radiotherapy can cause adverse skin reactions over the course of their treatment. Currently, management is based on several tropical products although there is no gold-standard approach to prevention and management of radiation toxicity. Method: We report our experience of vitamin E acetate in the treatment of radiation dermatitis in breast cancer patients who experienced grade 4 side effects (according to Radiation Therapy Oncology Group criteria). Results: Clinical management consisted of oral antibiotics and local application of vitamin E acetate and local escarectomy. All of the patients achieved complete re-epithelialization within 40 days. Conclusion: Skin ulceration and necrosis post-radiation may interrupt oncological treatment in breast cancer patients. In acute radiodermatitis with skin necrosis, we propose the use of oral antibiotics together with escarectomy and the application of vitamin E acetate to facilitate the healing process in order to minimize the interruption to the oncological treatment. © the authors; licensee ecancermedicalscience.
ISSN: 17546605
Appears in Collections:Scopus 2006-2010

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