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|Title:||Acute radiation dermatitis in breast cancer: Topical therapy with vitamin E acetate in lipophilic gel base|
B. A. Jereczek
M. C. Leonardi
J. Y. Petit
Istituto Europeo di Oncologia
Universita degli Studi di Milano
|Keywords:||Biochemistry, Genetics and Molecular Biology;Medicine|
|Citation:||ecancermedicalscience. Vol.4, No.1 (2010)|
|Abstract:||Background: Radiotherapy can cause adverse skin reactions over the course of their treatment. Currently, management is based on several tropical products although there is no gold-standard approach to prevention and management of radiation toxicity. Method: We report our experience of vitamin E acetate in the treatment of radiation dermatitis in breast cancer patients who experienced grade 4 side effects (according to Radiation Therapy Oncology Group criteria). Results: Clinical management consisted of oral antibiotics and local application of vitamin E acetate and local escarectomy. All of the patients achieved complete re-epithelialization within 40 days. Conclusion: Skin ulceration and necrosis post-radiation may interrupt oncological treatment in breast cancer patients. In acute radiodermatitis with skin necrosis, we propose the use of oral antibiotics together with escarectomy and the application of vitamin E acetate to facilitate the healing process in order to minimize the interruption to the oncological treatment. © the authors; licensee ecancermedicalscience.|
|Appears in Collections:||Scopus 2006-2010|
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