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Title: Molecular targets of apigenin in colorectal cancer cells: Involvement of p21, NAG-1 and p53
Authors: Yi Zhong
Chutwadee Krisanapun
Seong Ho Lee
Thararat Nualsanit
Carl Sams
Penchom Peungvicha
Seung Joon Baek
University of Tennessee, Knoxville
Shuguang Hospital
Srinakharinwirot University
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Dec-2010
Citation: European Journal of Cancer. Vol.46, No.18 (2010), 3365-3374
Abstract: Persuasive epidemiological and experimental evidence suggests that dietary flavonoids have anti-cancer activity. Since conventional therapeutic and surgical approaches have not been able to fully control the incidence and outcome of most cancer types, including colorectal neoplasia, there is an urgent need to develop alternative approaches for the management of cancer. We sought to develop the best flavonoids for the inhibition of cell growth, and apigenin (flavone) proved to be the most promising compound in colorectal cancer cell growth arrest. Subsequently, we found that pro-apoptotic proteins (NAG-1 and p53) and cell cycle inhibitor (p21) were induced in the presence of apigenin, and kinase pathways, including PKCδ and ataxia telangiectasia mutated (ATM), play an important role in activating these proteins. The data generated by in vitro experiments were confirmed in an animal study using APCMIN+mice. Apigenin is able to reduce polyp numbers, accompanied by increasing p53 activation through phosphorylation in animal models. Our data suggest apparent beneficial effects of apigenin on colon cancer. © 2010 Elsevier Ltd. All rights reserved.
ISSN: 09598049
Appears in Collections:Scopus 2006-2010

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