Please use this identifier to cite or link to this item:
|Title:||Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria|
|Authors:||Sudha B. Singh|
University of New Mexico Health Sciences Center
The Cancer Institute of New Jersey
Tokyo Metropolitan Institute of Medical Science
Juntendo University School of Medicine
|Keywords:||Biochemistry, Genetics and Molecular Biology|
|Citation:||Nature Cell Biology. Vol.12, No.12 (2010), 1154-1165|
|Abstract:||IRGM, a human immunity-related GTPase, confers autophagic defence against intracellular pathogens by an unknown mechanism. Here, we report an unexpected mode of IRGM action. IRGM demonstrated differential affinity for the mitochondrial lipid cardiolipin, translocated to mitochondria, affected mitochondrial fission and induced autophagy. Mitochondrial fission was necessary for autophagic control of intracellular mycobacteria by IRGM. IRGM influenced mitochondrial membrane polarization and cell death. Overexpression of IRGMd, but not IRGMb splice isoforms, caused mitochondrial depolarization and autophagy-independent, but Bax/Bak-dependent, cell death. By acting on mitochondria, IRGM confers autophagic protection or cell death, explaining IRGM action both in defence against tuberculosis and in the damaging inflammation caused by Crohn's disease. © 2010 Macmillan Publishers Limited. All rights reserved.|
|Appears in Collections:||Scopus 2006-2010|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.