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Title: Part 1: Antiplasmodial, cytotoxic, radical scavenging and antioxidant activities of thai plants in the family acanthaceae
Authors: Panarat Charoenchai
Srunya Vajrodaya
Winai Somprasong
Chulabhorn Mahidol
Somsak Ruchirawat
Prasat Kittakoop
Chulabhorn Research Institute
Kasetsart University
Thailand Ministry of Agriculture and Cooperatives
Chulabhorn Graduate Institute
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 22-Nov-2010
Citation: Planta Medica. Vol.76, No.16 (2010), 1940-1943
Abstract: Crude extracts (CH2Cl2 and MeOH) of 20 plants in the family Acanthaceae were screened for their antiplasmodial, cytotoxic, antioxidant, and radical scavenging activities. These plants included Asystasia nemorum, Barleria cristata, B. strigosa, Dicliptera burmanni, Eranthemum tetragonum, Hygrophila ringens, Justicia balansae, J. procumbens, Lepidagathis incurva, Peristrophe lanceolaria, Phaulopsis dorsiflora, Ruellia kerrii, Strobilanthes auriculata, S. corrugata, S. cusia, S. dimorphotricha, S. karensium, S. maxwellii, S. pateriformis, and S. brandisii. CH 2Cl2 extracts of A. nemorum, S. corrugata, S. cusia, S. maxwellii, S. pateriformis, and S. brandisii, as well as MeOH extracts of J. balansae and J. procumbens, showed antiplasmodial activity with IC50 values of 10100μg/mL. CH2Cl2 extracts of nine plants including D. burmanni, H. ringens, J. balansae, J. procumbens, L. incurva, P. lanceolaria, P. dorsiflora, S. corrugata, and S. maxwellii showed cytotoxic activity with IC50 values of 3.546.0μg/mL. MeOH extracts (at 100μg/mL) of R. kerrii and S. auriculata could effectively scavenge DPPH free radicals (8283% inhibition) and superoxide anion radicals (79% and 88% inhibition). In the ORAC antioxidant assay, MeOH extracts of B. cristata, J. procumbens, R. kerrii, and S. auriculata exhibited activity with ORAC units of 3.13.9. © Georg Thieme Verlag KG Stuttgart · New York.
ISSN: 14390221
Appears in Collections:Scopus 2006-2010

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