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Title: Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study
Authors: Norbert Gattermann
Carlo Finelli
Matteo Della Porta
Pierre Fenaux
Arnold Ganser
Agnes Guerci-Bresler
Mathias Schmid
Kerry Taylor
Dominique Vassilieff
Dany Habr
Gabor Domokos
Bernard Roubert
Christian Rose
L. Agaoglu
G. Alimena
D. Alonso
S. Ame
E. Angelucci
B. Arrizabalaga
M. Athanasiou-Metaxa
B. Augustson
Y. Aydinok
A. Baba
M. Baccarani
J. Beck
P. Beris
O. Beyne-Rauzy
H. Birgens
D. Bordessoule
C. Borgna-Pignatti
A. Bosly
K. Bouabdallah
D. Bowden
D. Bowen
D. Bron
M. D. Cappellini
M. Capra
G. Cartron
M. Cazzola
C. Chalkias
L. L. Chan
S. Chancharunee
C. Chapman
P. Charoenkwan
E. Chasapopoulou
S. Cheze
A. Chuansumrit
P. Cianciulli
C. Dauriac
M. Delforge
G. Dölken
H. Dombret
J. Duyster
T. Economopoulos
G. Ehninger
M. Elalfy
A. El-Beshlawy
L. Enggaard
G. Fillet
A. Filosa
G. Forni
R. Galanello
G. Gastl
S. Giraudier
A. Goldfarb
A. Grigg
F. Gumruk
S. Y. Ha
D. Haase
B. Heinrich
M. Hertzberg
J. Ho
H. C. Hsu
S. Huang
M. Hunault-Berger
B. Inusa
D. Jaulmes
J. Jensen
A. Kattamis
Y. Kilinc
K. H. Kim
S. Kinsey
L. Kjeldsen
A. Koren
M. E. Lai
Y. Lai
J. W. Lee
K. H. Lee
S. H. Lee
L. Legros
C. Li
C. K. Li
Q. Li
K. H. Lin
W. Linkesch
M. Lübbert
D. Lutz
A. J. Mohamed Thalha
G. Mufti
P. Muus
Heinrich Heine Universitat
Alma Mater Studiorum Universita di Bologna
Universita degli Studi di Pavia
Hopital Avicenne
Medizinische Hochschule Hannover (MHH)
Hopital Brabois Adultes
Universitatsklinikum Ulm
Mater Hospital
Universite Paris Descartes
Novartis Pharmaceuticals
Novartis International AG
Hopital Saint Vincent-de-Paul GHICL
Istanbul Universitesi
Azienda Policlinico Umberto I
Hospital Universitario Virgen del Rocio
Hopital de Hautepierre
Azienda Ospedaliera Brotzu - Businco
Hospital de Cruzes
Aristotle University of Thessaloniki
Sir Charles Gairdner Hospital
Ege Universitesi
Hospital Universiti Sains Malaysia
Osp. Bologna
Klinikum der Johannes-Gutenberg-Universitat und Fachbereich Medizin
Hopitaux universitaires de Geneve
Hopital Purpan
Amtssygehusetl Herlev
CHU de Limoges
Az. Ospedaliera Universitaria St. Anna
Cliniques Universitaires UCL
CHU Hopitaux de Bordeaux
Monash Medical Centre
Leeds General Infirmary
Institut Jules Bordet
Universita degli Studi di Milano
Ospedale Civico M. Ascoli
Clinique Victor Hugo
Fondazione IRCCS Policlinico San Matteo
Larissa General Hospital
University of Malaya Medical Centre
Mahidol University
Leicester Royal Infirmary
Chiang Mai University
University Hospitalof Thessaloniki AHEPA
Hopital Clemenceau
Ospedale S. Eugenio
Hopital Pontchaillou
KU Leuven– University Hospital Leuven
Ernst-Moritz-Arndt-Universitat Greifswald
Hopital Saint-Louis
Technical University of Munich
University of Athens Medical School
Dresden University Faculty of Medicine and University Hospital Carl Gustav Carus
Ain Shams University
Cairo University
Hillerod Hospital
Centre Hospitalier Universitaire de Liege
Azienda Ospedaliera Di Rilievo Nazionale Antonio Cardarelli
E.O. Ospedali Galliera
Azienda Ospedaliera Brotzu - Microcitemico
Medizinische Universitat Innsbruck
Hopital Henri Mondor
Hadassah University Medical Centre
Royal Melbourne Hospital
Hacettepe Universitesi
Queen Mary Hospital Hong Kong
Universitatsmedizin Gottingen
Gemeinschaftspraxis Brudler/ Heinrich
Westmead Hospital
Royal Prince Alfred Hospital
Veterans General Hospital-Taipei
Guang Zhou Zhong Shan No.2 Hospital
CHU Angers
Evelina Children's Hospital
Hopital Saint-Antoine
Aarhus Amtssygehus, Aarhus University Hospital
University of Athens
Cukurova Universitesi
Samsung Medical Center, Sungkyunkwan University
St James's University Hospital
Emek Medical Center
Hospital of Nanjing Medical University
The Catholic University of Korea
Asan Medical Center
Royal Adelaide Hospital
Centre Hospitalier Universitaire de Nice, Hopital l'Archet
Nanfang Hospital
Prince of Wales Hospital Hong Kong
Branch of Shanghai No.1 Hospital
National Taiwan University Hospital
LKH-Universitatsklinikum Graz
Universitats Klinikum Freiburg und Medizinische Fakultat
A. Ö. Krankenhausder Elisabethinen
Hospital Universiti Kebangsaan Malaysia
King's College Hospital NHS Foundation Trust
Radboud University Nijmegen Medical Centre
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Sep-2010
Citation: Leukemia Research. Vol.34, No.9 (2010), 1143-1150
Abstract: The prospective 1-year EPIC study enrolled 341 patients with myelodysplastic syndromes (MDS); although baseline iron burden was >2500. ng/mL, ∼50% were chelation-naïve. Overall median serum ferritin decreased significantly at 1 year (p=0.002). Decreases occurred irrespective of whether patients were chelation-naïve or previously chelated; changes were dependent on dose adjustments and ongoing iron intake. Sustained reductions in labile plasma iron were observed. Discontinuation rate (48.7%) and adverse event profile were consistent with previously reported deferasirox data in MDS. Alanine aminotransferase levels decreased significantly; change correlated significantly with reduction in serum ferritin (p<0.0001). This large dataset prospectively confirms the efficacy and well characterizes the safety profile of deferasirox in MDS. © 2010 Elsevier Ltd.
ISSN: 01452126
Appears in Collections:Scopus 2006-2010

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