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Title: Bacillus subtilis SSE4 produces subtulene A, a new lipopeptide antibiotic possessing an unusual C15 unsaturated β-amino acid
Authors: Nopporn Thasana
Benjaphorn Prapagdee
Nuchanart Rangkadilok
Ratiboot Sallabhan
Seaim Lwin Aye
Somsak Ruchirawat
Suvit Loprasert
Chulabhorn Graduate Institute
Chulabhorn Research Institute
Faculty of Environment and Resource Studies, Mahidol University
Center of Excellence on Environmental Health
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jul-2010
Citation: FEBS Letters. Vol.584, No.14 (2010), 3209-3214
Abstract: Subtulene A, a new cyclic lipopeptide, was isolated from the culture broth of Bacillus subtilis SSE4. This antibiotic compound contained the seven common α-amino acids, l-Asn-1, d-Tyr-2, d-Asn-3, l-Gln-4, l-Pro-5, d-Asn-6, l-Ser-7 and the unique β-amino acid-8 present in the iturin family. 1D and 2D NMR, as well as MS analyses, identified the β-amino acid as 3-amino-13-methyltetradec-8-enoic acid, an Iso C15 long chain β-amino acid. B. subtilis SSE4 was also found to produce iturin A. B. subtilis SSE4 culture filtrate exhibited both antifungal and antibacterial activities. © 2010 Federation of European Biochemical Societies.
ISSN: 00145793
Appears in Collections:Scopus 2006-2010

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