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Title: Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th international histocompatibility workshop: Worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA
Authors: J. A. Hollenbach
A. Meenagh
C. Sleator
C. Alaez
M. Bengoche
A. Canossi
G. Contreras
L. Creary
I. Evseeva
C. Gorodezky
R. A. Hardie
T. Hemming Karlsen
B. Lie
M. Luo
M. Martinetti
C. Navarette
D. C.M. De Oliveira
G. Ozzella
A. Pasi
E. Pavlova
S. Pinto
L. C. Porto
P. Santos
A. Slavcev
D. Srinak
S. Tavoularis
S. Tonks
E. Trachtenberg
S. Vejbaesya
D. Middleton
UCSF Benioff Children's Hospital Oakland
Northern Ireland Histocompatibility
Instituto Nacional de Diagnostico y Referencia Epidemiologicos
Instituto Nacional de Donación y Trasplante (INDT
Consiglio Nazionale delle Ricerche
University of Oxford
University of Manitoba
Rikshospitalet-Radiumhospitalet HF
Fondazione IRCCS Policlinico San Matteo
Universidade do Estado do Rio de Janeiro
Institutu Klinicke a Experimentalni Mediciny
Centre for Histocompatibility of the Centre
Mahidol University
Canadian Blood Services
Weatherall Institute of Molecular Medicine
University of Liverpool
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine
Issue Date: 1-Jul-2010
Citation: Tissue Antigens. Vol.76, No.1 (2010), 9-17
Abstract: The killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop (IHIWS) sought to explore worldwide population variation in the KIR loci, and to examine the relationship between KIR genes and their human leukocyte antigen (HLA) ligands. Fifteen laboratories submitted KIR genotype and HLA ligand data in 27 populations from six broad ethnic groups. Data were analyzed for correlations between the frequencies of KIR and their known HLA ligands. In addition, allelic typing was performed for KIR2DL2 and 3DL1 in a subset of populations. Strong and significant correlations were observed between KIR2DL2, 2DL3 genotype frequencies and the frequency of their ligand, HLA-C1. In contrast, only weak associations were seen for 3DL1, 3DS1 and the HLA-Bw4 ligand. Although some aspects of the correlations observed here differ from those reported in other populations, these data provide additional evidence of linked evolutionary histories for some KIR and HLA loci. Investigation of allele-level variation for the B haplotype locus KIR 2DL2 showed that two alleles, *001 and *003, predominate in all populations in this study. Much more allelic variation was observed for the A haplotype locus 3DL1, with several alleles observed at moderate frequencies and extensive variation observed between populations. © 2010 John Wiley & Sons A/S.
ISSN: 13990039
Appears in Collections:Scopus 2006-2010

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