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Title: Glutarimide alkaloids and a terpenoid benzoquinone from Cordia globifera
Authors: Joshua Parks
Thinley Gyeltshen
Vilailak Prachyawarakorn
Chulabhorn Mahidol
Somsak Ruchirawat
Prasat Kittakoop
Chulabhorn Research Institute
University of Portland
Chulabhorn Graduate Institute
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 28-May-2010
Citation: Journal of Natural Products. Vol.73, No.5 (2010), 992-994
Abstract: Three new compounds, a meroterpene (2) having a cyclopropane moiety named globiferane and glutarimide alkaloids named cordiarimides A (3) and B (4), were isolated from the roots of Cordia globifera. Compounds 2-4 exhibited weak cytotoxic activity. Cordiarimide B (4) exhibited radical scavenging activity, as it inhibited superoxide anion radical formation in the xanthine/xanthine oxidase (XXO) assay, and also suppressed superoxide anion generation in differentiated HL-60 human promyelocytic leukemia cells when induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). This is the first report on the presence of glutarimide alkaloids in the genus Cordia. © 2010 The American Chemical Society and American Society of Pharmacognosy.
ISSN: 15206025
Appears in Collections:Scopus 2006-2010

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