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Title: Anti-HIV1 Diterpenoids from Leaves and Twigs of Polyalthia sclerophylla
Authors: Siriporn Saepou
Manat Pohmakotr
Vichai Reutrakul
Chalobon Yoosook
Jitra Kasisit
Chanita Napaswad
Patoomratana Tuchinda
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 14-May-2010
Citation: Planta Medica. Vol.76, No.7 (2010), 721-725
Abstract: Bioassay-guided fractionation and purification of the anti-HIV-1-active MeOH extract from the leaves and twigs of Polyalthia sclerophylla led to the isolation of two new compounds, ent-kaur-sclerodimer (1) and cyclotucanol 3-palmitate (2), along with the known ent-kaur-16-en-19-oic acid (3), 15-hydroxy-ent-kaur-16-en-19-oic acid (4), 15-acetoxy-ent-kaur-16-en-19-oic acid (5), 15-oxo-ent-kaur-16-en-19-oic acid (6), 16,17-dihydroxy-ent-kauran-19-oic acid (7), 16-hydroxy-ent-kauran-19-oic acid (xylopic acid) (8), a pseudodimer (15-hydroxy-ent-kaur-16-en-19-oic acid/17-hydroxy-ent-kaur-15-en-19-oic acid) (9), ermanin, nicotiflorin, and allantoin. Among these isolates, compound 3 was the most active in both anti-syncytium (EC5013.7μg/mL and selectivity index 3.1) and HIV-1 reverse transcriptase (IC5034.1μg/mL) assays. © Georg Thieme Verlag KG Stuttgart.
ISSN: 14390221
Appears in Collections:Scopus 2006-2010

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