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Title: Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
Authors: Rachel M. Freathy
Dennis O. Mook-Kanamori
Ulla Sovio
Inga Prokopenko
Nicholas J. Timpson
Diane J. Berry
Nicole M. Warrington
Elisabeth Widen
Jouke Jan Hottenga
Marika Kaakinen
Leslie A. Lange
Jonathan P. Bradfield
Marjan Kerkhof
Julie A. Marsh
Reedik Mägi
Chih Mei Chen
Helen N. Lyon
Mirna Kirin
Linda S. Adair
Yurii S. Aulchenko
Amanda J. Bennett
Judith B. Borja
Nabila Bouatia-Naji
Pimphen Charoen
Lachlan J.M. Coin
Diana L. Cousminer
Eco J.C. De Geus
Panos Deloukas
Paul Elliott
David M. Evans
Philippe Froguel
Beate Glaser
Christopher J. Groves
Anna Liisa Hartikainen
Neelam Hassanali
Joel N. Hirschhorn
Albert Hofman
Jeff M.P. Holly
Elina Hyppönen
Stavroula Kanoni
Bridget A. Knight
Jaana Laitinen
Cecilia M. Lindgren
Wendy L. McArdle
Paul F. O'Reilly
Craig E. Pennell
Dirkje S. Postma
Anneli Pouta
Adaikalavan Ramasamy
Nigel W. Rayner
Susan M. Ring
Fernando Rivadeneira
Beverley M. Shields
David P. Strachan
Ida Surakka
Anja Taanila
Carla Tiesler
Andre G. Uitterlinden
Cornelia M. Van Duijn
Alet H. Wijga
Gonneke Willemsen
Haitao Zhang
Jianhua Zhao
James F. Wilson
Eric A.P. Steegers
Andrew T. Hattersley
Johan G. Eriksson
Leena Peltonen
Karen L. Mohlke
Struan F.A. Grant
Hakon Hakonarson
University of Exeter
Erasmus University Medical Center
Imperial College London
University of Oxford
Wellcome Trust Centre for Human Genetics
Medical Research Council
University of Western Australia
Helsingin Yliopisto
Vrije Universiteit Amsterdam
Oulun Yliopisto
The University of North Carolina at Chapel Hill
The Children's Hospital of Philadelphia
University of Groningen, University Medical Center Groningen
Helmholtz Center Munich German Research Center for Environmental Health
Klinikum der Universitat Munchen
Children's Hospital Boston
Harvard Medical School
University of Edinburgh
University of San Carlos
CNRS Centre National de la Recherche Scientifique
University of Lille
Mahidol University
Wellcome Trust Sanger Institute
Hammersmith Hospital
University of Bristol
Massachusetts Institute of Technology
Harokopio University
University of Western Australia Faculty of Medicine and Dentistry
National Institute for Health and Welfare
National Heart and Lung Institute
University of London
National Institute of Public Health and the Environment
Helsinki University Hospital
National Institute for Health and Welfare
University of Pennsylvania, School of Medicine
University Medical Center Groningen, Centre for Revalidation (Beatrix Children's Hospital)
Churchill Hospital
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-May-2010
Citation: Nature Genetics. Vol.42, No.5 (2010), 430-435
Abstract: To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 × 10 35) and rs9883204 in ADCY5 (P = 7 × 10 15) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113g (95% CI 89-137g) lighter at birth than the 24% with zero or one alleles (P trend = 7 × 10 30). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy. © 2010 Nature America, Inc. All rights reserved.
ISSN: 15461718
Appears in Collections:Scopus 2006-2010

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