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Title: A comparative study of the serological response to Japanese encephalitis vaccine in HIV-infected and uninfected Thai children
Authors: Kulkanya Chokephaibulkit
Nottasorn Plipat
Sutee Yoksan
Wanatpreeya Phongsamart
Keswadee Lappra
Pimpanada Chearskul
Sanay Chearskul
Orasri Wittawatmongkol
Nirun Vanprapar
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine
Issue Date: 30-Apr-2010
Citation: Vaccine. Vol.28, No.20 (2010), 3563-3566
Abstract: We report a prospective study of mouse brain derived inactivated Japanese encephalitis (JE) vaccine, given in 3-dose EPI program to human immune deficiency virus (HIV)-exposed Thai infants. 18 HIV-infected receiving antiretroviral therapy with median baseline CD4 of 33.1%, and 92 HIV-uninfected children were studied. All but one HIV-infected child seroconverted after the second dose. The geometric mean titers (GMTs) 3 months after the second and third doses in HIV-infected vs HIV-uninfected children were 247 vs 938 (p = 0.022), and 2273 vs 24069 (p = 0.009), respectively. Urticaria or angioedema found in 4% and 6% in HIV-infected and -uninfected children, respectively (p = 1.0). The vaccine was safe and immunogenic but antibody response in HIV-infected children was not as high as in uninfected children. © 2010 Elsevier Ltd. All rights reserved.
ISSN: 0264410X
Appears in Collections:Scopus 2006-2010

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