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Title: Labdane diterpenes from the aerial parts of curcuma comosa enhance fetal hemoglobin production in an erythroid cell line
Authors: Ratchanaporn Chokchaisiri
Nattawara Chaneiam
Saovaros Svasti
Suthat Fucharoen
Jim Vadolas
Apichart Suksamrarn
Ramkhamhaeng University
Mahidol University
Royal Children's Hospital, Melbourne
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 23-Apr-2010
Citation: Journal of Natural Products. Vol.73, No.4 (2010), 724-728
Abstract: Three new labdane diterpenes, curcucomosins A-C (1-3), four known labdane diterpenes, 4-7, and a known diarylheptanoid, 8, were isolated from the aerial parts of Curcuma comosa. The structures of the new diterpenes were elucidated by spectroscopic data analysis. The fetal hemoglobin (Hb F) induction potency of the isolated compounds was examined using a K562 reporter cell line harboring the enhanced green fluorescence protein (EGFP) gene under the control of a Gγ-globin promoter. Compound 6, isocoronarin D, exhibited the highest Hb F induction effect of 1.6-fold at 20 μM. © 2010 The American Chemical Society and American Society of Pharmacognosy.
ISSN: 15206025
Appears in Collections:Scopus 2006-2010

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