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Title: Analyses of the regulatory mechanism and physiological roles of Pseudomonas aeruginosa OhrR, a transcription regulator and a sensor of organic hydroperoxides
Authors: Sopapan Atichartpongkul
Mayuree Fuangthong
Paiboon Vattanaviboon
Skorn Mongkolsuk
Chulabhorn Research Institute
Chulabhorn Graduate Institute
Mahidol University
Center for Environmental Health
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 1-Apr-2010
Citation: Journal of Bacteriology. Vol.192, No.8 (2010), 2093-2101
Abstract: ohrR encodes an organic hydroperoxide sensor and a transcriptional repressor that regulates organic hydroperoxide-inducible expression of a thiol peroxidase gene, ohr, and itself. OhrR binds directly to the operators and represses transcription of these genes. Exposure to an organic hydroperoxide leads to oxidation of OhrR and to subsequent structural changes that result in the loss of the repressor's ability to bind to the operators that allow expression of the target genes. Differential induction of ohrR and ohr by tert-butyl hydroperoxide suggests that factors such as the repressor's dissociation constants for different operators and the chemical nature of the inducer contribute to OhrR-dependent organic hydroperoxide-inducible gene expression. ohrR and ohr mutants show increased and decreased resistance to organic hydroproxides, respectively, compared to a parental strain. Moreover, the ohrR mutant had a reduced-virulence phenotype in the Pseudomonas aeruginosa-Caenorhabditis elegans pathogenicity model. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
ISSN: 00219193
Appears in Collections:Scopus 2006-2010

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