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dc.contributor.authorSopapan Atichartpongkulen_US
dc.contributor.authorMayuree Fuangthongen_US
dc.contributor.authorPaiboon Vattanaviboonen_US
dc.contributor.authorSkorn Mongkolsuken_US
dc.contributor.otherChulabhorn Research Instituteen_US
dc.contributor.otherChulabhorn Graduate Instituteen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherCenter for Environmental Healthen_US
dc.date.accessioned2018-09-24T08:46:31Z-
dc.date.available2018-09-24T08:46:31Z-
dc.date.issued2010-04-01en_US
dc.identifier.citationJournal of Bacteriology. Vol.192, No.8 (2010), 2093-2101en_US
dc.identifier.issn00219193en_US
dc.identifier.other2-s2.0-77950682314en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77950682314&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/28746-
dc.description.abstractohrR encodes an organic hydroperoxide sensor and a transcriptional repressor that regulates organic hydroperoxide-inducible expression of a thiol peroxidase gene, ohr, and itself. OhrR binds directly to the operators and represses transcription of these genes. Exposure to an organic hydroperoxide leads to oxidation of OhrR and to subsequent structural changes that result in the loss of the repressor's ability to bind to the operators that allow expression of the target genes. Differential induction of ohrR and ohr by tert-butyl hydroperoxide suggests that factors such as the repressor's dissociation constants for different operators and the chemical nature of the inducer contribute to OhrR-dependent organic hydroperoxide-inducible gene expression. ohrR and ohr mutants show increased and decreased resistance to organic hydroproxides, respectively, compared to a parental strain. Moreover, the ohrR mutant had a reduced-virulence phenotype in the Pseudomonas aeruginosa-Caenorhabditis elegans pathogenicity model. Copyright © 2010, American Society for Microbiology. All Rights Reserved.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77950682314&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleAnalyses of the regulatory mechanism and physiological roles of Pseudomonas aeruginosa OhrR, a transcription regulator and a sensor of organic hydroperoxidesen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1128/JB.01510-09en_US
Appears in Collections:Scopus 2006-2010

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