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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/28759
Title: Anti-HIV1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi
Authors: Vichai Reutrakul
Natthinee Anantachoke
Manat Pohmakotr
Thaworn Jaipetch
Chalobon Yoosook
Jittra Kasisit
Chanita Napaswa
Ampai Panthong
Thawatchai Santisuk
Samran Prabpai
Palangpon Kongsaeree
Patoomratana Tuchinda
Mahidol University
Chiang Mai University
Thailand Royal Forest Department
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 12-Mar-2010
Citation: Planta Medica. Vol.76, No.4 (2010), 368-371
Abstract: Two new lupanes, 2-acetoxy-3-hydroxy-19-hydrogen-lup-20(29)-en-28-oic acid (2-acetoxyalphitolic acid) (1) and 2-hydroxy-3-acetoxy-19-hydrogen-lup-20(29)- en-28-oic acid (3-acetoxyalphitolic acid) (2), together with the known betulinic acid (3), betulin (4), and stimasterol-3-O - D-glucopyranoside (5), were isolated from the leaves and twigs of Garcinia hanburyi. Compounds 13 were also isolated from the resin of this plant. The structure of 2 was confirmed by single-crystal X-ray diffraction analysis. All of the lupanes (14) displayed anti-HIV1 activities in the anti-HIV1 reverse transcriptase (ICvalues 16.3116.9g/mL) and syncytium assays (EC5.673.6g/mL, SI 1.73.3). Moreover compounds 14 exhibited anti-inflammatory activity in an ethyl phenylpropiolate (EPP)-induced ear edema model. © Georg Thieme Verlag KG Stuttgart New York.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77749316840&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/28759
ISSN: 14390221
00320943
Appears in Collections:Scopus 2006-2010

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