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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/28764
Title: Dengue virus - Induced hemorrhage in a nonhuman primate model
Authors: Nattawat Onlamoon
Sansanee Noisakran
Hui Mien Hsiao
Alexander Duncan
Francois Villinger
Aftab A. Ansari
Guey Chuen Perng
Emory University School of Medicine
Mahidol University
Thailand National Center for Genetic Engineering and Biotechnology
Emory University
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine
Issue Date: 4-Mar-2010
Citation: Blood. Vol.115, No.9 (2010), 1823-1834
Abstract: Lack of a dengue hemorrhagic animal model recapitulating human dengue virus infection has been a significant impediment in advancing our understanding of the early events involved in the pathogenesis of dengue disease. In efforts to address this issue, a group of rhesus macaques were intravenously infected with dengue virus serotype 2 (strain 16 681) at 1 × 107 PFU/animal. A classic dengue hemorrhage developed 3 to 5 days after infection in 6 of 6 animals. Blood chemistry appeared to be normal with exception of creatine phosphokinase, which peaked at 7 days after infection. A modest thrombocytopenia and noticeable neutropenia concomitant with slight decrease of hemoglobin and hematocrit were registered. In addition, the concentration of D-dimer was elevated significantly. Viremia peaked at 3 to 5 days after infection followed by an inverse relationship between T and B lymphocytes and a bimodal pattern for platelet-monocytes and platelet-neutrophil aggregates. Dengue virus containing platelets engulfed by monocytes was noted at 8 or 9 days after infection. Thus, rhesus macaques inoculated intravenously with a high dose of dengue virus produced dengue hemorrhage, which may provide a unique platform to define the early events in dengue virus infection and help identify which blood components contribute to the pathogenesis of dengue disease. © 2010 by The American Society of Hematology.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77950346597&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/28764
ISSN: 15280020
00064971
Appears in Collections:Scopus 2006-2010

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