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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/28796
Title: Accuracy of accessbio immunoglobulin M and total antibody rapid immunochromatographic assays for the diagnosis of acute scrub typhus infection
Authors: Stuart D. Blacksell
Kemajittra Jenjaroen
Rattanaphone Phetsouvanh
Vanaporn Wuthiekanun
Nicholas P.J. Day
Paul N. Newton
Wei Mei Ching
Mahidol University
University of Oxford
Mahosot Hospital
Naval Medical Research Center
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine
Issue Date: 1-Feb-2010
Citation: Clinical and Vaccine Immunology. Vol.17, No.2 (2010), 263-266
Abstract: Using archived samples, we assessed the diagnostic capacity of a rapid immunochromatographic test (ICT) for the detection of Orientia tsutsugamushi IgM and total antibodies to aid with the diagnosis of acute scrub typhus infection in febrile patients in Laos. The sensitivity and the specificity of the ICT for the detection of IgM were 96.8% (121/125 samples; 95% confidence interval [CI], 92.1 to 99.1%) and 93.3% (98/105 samples; 95% CI, 86.7 to 97.3%), respectively. For the detection of total antibodies, the sensitivity was 97.6% (122/125 samples; 95% CI, 93.1 to 99.5%), but the specificity was much lower, at 71.4% (75/105 samples; 95% CI, 61.8 to 79.8%). Copyright © 2010, American Society for Microbiology. All Rights Reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=75749146669&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/28796
ISSN: 1556679X
15566811
Appears in Collections:Scopus 2006-2010

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