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Title: International epidemiology of human pre-existing adenovirus (Ad) type-5, type-6, type-26 and type-36 neutralizing antibodies: Correlates of high Ad5 titers and implications for potential HIV vaccine trials
Authors: T. Christopher Mast
Lisa Kierstead
Swati B. Gupta
Alexander A. Nikas
Esper G. Kallas
Vladimir Novitsky
Bernard Mbewe
Punee Pitisuttithum
Mauro Schechter
Eftyhia Vardas
Nathan D. Wolfe
Miguel Aste-Amezaga
Danilo R. Casimiro
Paul Coplan
Walter L. Straus
John W. Shiver
Merck Research Laboratories
Universidade Federal de Sao Paulo
Harvard School of Public Health
Malawi College of Medicine
Mahidol University
Universidade Federal do Rio
University of Witwatersrand
Johns Hopkins Bloomberg School of Public Health
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine
Issue Date: 22-Jan-2010
Citation: Vaccine. Vol.28, No.4 (2010), 950-957
Abstract: Replication-defective adenoviruses have been utilized as candidate HIV vaccine vectors. Few studies have described the international epidemiology of pre-existing immunity to adenoviruses. We enrolled 1904 participants in a cross-sectional serological survey at seven sites in Africa, Brazil, and Thailand to assess neutralizing antibodies (NA) for adenovirus types Ad5, Ad6, Ad26 and Ad36. Clinical trial samples were used to assess NA titers from the US and Europe. The proportions of participants that were negative were 14.8% (Ad5), 31.5% (Ad6); 41.2% (Ad26) and 53.6% (Ad36). Adenovirus NA titers varied by geographic location and were higher in non-US and non-European settings, especially Thailand. In multivariate logistic regression analysis, geographic setting (non-US and non-European settings) was statistically significantly associated with having higher Ad5 titers; participants from Thailand had the highest odds of having high Ad5 titers (adjusted OR = 3.53, 95% CI: 2.24, 5.57). Regardless of location, titers of Ad5NA were the highest and Ad36 NA were the lowest. Coincident Ad5/6 titers were lower than either Ad5 or Ad6 titers alone. Understanding pre-existing immunity to candidate vaccine vectors may contribute to the evaluation of vaccines in international populations. © 2009.
ISSN: 0264410X
Appears in Collections:Scopus 2006-2010

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