Simple jQuery Dropdowns
Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/28847
Title: High sequence variability among hemocyte-specific Kazal-type proteinase inhibitors in decapod crustaceans
Authors: Lage Cerenius
Haipeng Liu
Yanjiao Zhang
Vichien Rimphanitchayakit
Anchalee Tassanakajon
M. Gunnar Andersson
Kenneth Söderhäll
Irene Söderhäll
Uppsala Universitet
Xiamen University
Mahidol University
Uppsala Biomedicinska Centrum
Ocean University of China
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 1-Jan-2010
Citation: Developmental and Comparative Immunology. Vol.34, No.1 (2010), 69-75
Abstract: Crustacean hemocytes were found to produce a large number of transcripts coding for Kazal-type proteinase inhibitors (KPIs). A detailed study performed with the crayfish Pacifastacus leniusculus and the shrimp Penaeus monodon revealed the presence of at least 26 and 20 different Kazal domains from the hemocyte KPIs, respectively. Comparisons with KPIs from other taxa indicate that the sequences of these domains evolve rapidly. A few conserved positions, e.g. six invariant cysteines were present in all domain sequences whereas the position of P1 amino acid, a determinant for substrate specificity, varied highly. A study with a single crayfish animal suggested that even at the individual level considerable sequence variability among hemocyte KPIs produced exist. Expression analysis of four crayfish KPI transcripts in hematopoietic tissue cells and different hemocyte types suggest that some of these KPIs are likely to be involved in hematopoiesis or hemocyte release as they were produced in particular hemocyte types or maturation stages only. © 2009 Elsevier Ltd. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70349998712&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/28847
ISSN: 0145305X
Appears in Collections:Scopus 2006-2010

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.