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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/28848
Title: HMGB1: A new marker for estimation of the postmortem interval
Authors: Kiyoshi Kikuchi
Ko ichi Kawahara
Kamal Krishna Biswas
Takashi Ito
Salunya Tancharoen
Naoto Shiomi
Yoshiro Koda
Fumiyo Matsuda
Yoko Morimoto
Yoko Oyama
Kazunori Takenouchi
Naoki Miura
Noboru Arimura
Yuko Nawa
Shinichiro Arimura
Meng Xiao Jie
Binita Shrestha
Masahiro Iwata
Kentaro Mera
Hisayo Sameshima
Yoshiko Ohno
Ryuichi Maenosono
Yutaka Tajima
Hisaaki Uchikado
Terukazu Kuramoto
Kenji Nakayama
Minoru Shigemori
Yoshihiro Yoshida
Teruto Hashiguchi
Ikuro Maruyama
Division of Laboratory and Vascular Medicine
Kagoshima University Faculty of Medicine
Kagoshima University
Omuta City General Hospital
Saiseikai Shiga Hospital
Kurume University School of Medicine
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 1-Jan-2010
Citation: Experimental and Therapeutic Medicine. Vol.1, No.1 (2010), 109-111
Abstract: Estimation of the postmortem interval (PMIPMIPMI) is one of the most important tasks in forensic medicine. Numerous methods have been proposed for the determination of the time since death by chemical means. High mobility group box-1 (HMHMGB1), a nonhistone DNADNADNA-binding protein is released by eukaryotic cells upon necrosis. Postmortem serum levels of HMGB1 of 90 male Wistar rats stored at 4, 14 and 24 °C since death were measured by enzyme-linked immunosorbent assay. The serum HMHMGB1 level showed a time-dependent increase up to seven days at 4 °C. At 14 °C, the HMGB1 level peaked at day 3, decreased at day 4, and then plateaued. At 24 °C, the HMHMGB1 level peaked at day 2, decreased at day 3, and then plateaued. Our findings suggest that HMGB1 is related to the PMIPMIPMI in rats.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77955784283&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/28848
ISSN: 17921015
17920981
Appears in Collections:Scopus 2006-2010

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