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|Title:||Synthesis of (+)-4-desoxypentenomycin and analogues|
|Citation:||Synthesis. No.9 (2010), 1453-1458|
|Abstract:||A synthesis of (+)-4-desoxypentenomycin is reported here; it involves diastereoselective phenylsulfanylpropylation of an enolate anion derived from methyl (2R,5R,6R)-5,6-dimethoxy-5,6-dimethyl[1,4]dioxane-2-carboxylate, obtained from D-mannitol, and is followed by sulfide oxidation, intramolecular acylation of the a-sulfinyl carbanion, sulfoxide elimination, and hydrolysis. Straightforward access to substituted analogues of (+)-4-desoxy-pentenomycin was also demonstrated by means of Suzuki-Miyaura, Sonogashira, and Heck coupling reactions. © Georg Thieme Verlag Stuttgart.|
|Appears in Collections:||Scopus 2006-2010|
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