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|Title:||Polymeric disinfectant nanocapsules: Effect of molecular weight of poly(methyl acrylate)|
Sirindhorn International Institute of Technology, Thammasat University
Thailand National Science and Technology Development Agency
Thailand National Center for Genetic Engineering and Biotechnology
|Keywords:||Chemical Engineering;Engineering;Materials Science;Medicine;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Journal of Biomedical Nanotechnology. Vol.6, No.4 (2010), 385-390|
|Abstract:||Poly(methyl acrylate) (PMA) of various weight average molecular weights (M̄w) were synthesized via the iniferter route and applied for the encapsulation of disinfectant agent (chlorhexidine digluconate; CHD) by using the controlled precipitation technique. The encapsulation efficiency of CHD-PMA nanocapsules suspended in cyclohexane increased from 70 to 100% when the M̄w of PMA increased from 40 K to 550 K. After redispersing the capsules into 0.5% w/v of sodium dodecyl sulphate aqueous solution, the maximum content of CHD in the nanocapsules remained >90%. Transmission electron micrographs showed the spherical nanocapsule with continuous intact shell. Copyright © 2010 American Scientific Publishers. All rights reserved.|
|Appears in Collections:||Scopus 2006-2010|
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