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Title: Polymeric disinfectant nanocapsules: Effect of molecular weight of poly(methyl acrylate)
Authors: Saovaree Tanpantree
Pakorn Opaprakasit
Duangporn Polpanich
Srung Smanmoo
Pramuan Tangboriboonrat
Mahidol University
Sirindhorn International Institute of Technology, Thammasat University
Thailand National Science and Technology Development Agency
Thailand National Center for Genetic Engineering and Biotechnology
Keywords: Chemical Engineering;Engineering;Materials Science;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Aug-2010
Citation: Journal of Biomedical Nanotechnology. Vol.6, No.4 (2010), 385-390
Abstract: Poly(methyl acrylate) (PMA) of various weight average molecular weights (M̄w) were synthesized via the iniferter route and applied for the encapsulation of disinfectant agent (chlorhexidine digluconate; CHD) by using the controlled precipitation technique. The encapsulation efficiency of CHD-PMA nanocapsules suspended in cyclohexane increased from 70 to 100% when the M̄w of PMA increased from 40 K to 550 K. After redispersing the capsules into 0.5% w/v of sodium dodecyl sulphate aqueous solution, the maximum content of CHD in the nanocapsules remained >90%. Transmission electron micrographs showed the spherical nanocapsule with continuous intact shell. Copyright © 2010 American Scientific Publishers. All rights reserved.
ISSN: 15507041
Appears in Collections:Scopus 2006-2010

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