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Title: Synthesis and characterization of bioactive molecules grafted on poly(e{open}-caprolactone) by " click" chemistry
Authors: Jiraphong Suksiriworapong
Kittisak Sripha
Varaporn Buraphacheep Junyaprasert
Mahidol University
Keywords: Chemistry;Materials Science
Issue Date: 1-May-2010
Citation: Polymer. Vol.51, No.11 (2010), 2286-2295
Abstract: A facile and efficient strategy to graft bioactive molecules (nicotinic acid, p-aminobenzoic acid, and phthaloyltryptophan) onto poly(e{open}-caprolactone) (P(e{open}CL)) was achieved by copper-catalyzed Huisgen's 1,3-dipolar cycloaddition known as click reaction. P(αCle{open}CL), with 10, 20, and 30% of α-chloro-e{open}-caprolactone (αCle{open}CL) units were copolymerized by ring opening polymerization using e{open}CL and αCle{open}CL as starting materials in the presence of 1,4-butanediol and Sn(Oct)2. Subsequently, the chloride pendent was converted to azide followed by cycloaddition with terminal alkyne derivatives of the aforementioned bioactive molecules. The complete addition was accomplished at all ratios. The characteristic molecular features of these copolymers were evaluated by FTIR, NMR, and GPC. Thermal analysis data indicated that the grafted compounds led to polymorphic alteration and different pattern of thermal degradation depending on the molecular structure and the size of the grafted compounds. They are the basis for further development of grafted copolymer as drug delivery carriers. © 2010.
ISSN: 00323861
Appears in Collections:Scopus 2006-2010

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