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Title: CD23-mediated cell signaling in human B cells differs from signaling in cells of the monocytic lineage
Authors: Marcia A. Chan
Nicole M. Gigliotti
Ponpan Matangkasombut
Stephen B. Gauld
John C. Cambier
Lanny J. Rosenwasser
Children's Mercy Hospitals and Clinics
Mahidol University
Harvard School of Public Health
Children's Research Institute
Medical College of Wisconsin
National Jewish Health
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Dec-2010
Citation: Clinical Immunology. Vol.137, No.3 (2010), 330-336
Abstract: CD23 is the low affinity receptor for IgE and in B cells CD23 has been proposed to play a role in the regulation of IgE synthesis. CD23 is expressed also on other cell types including monocytes/macrophages, eosinophils, follicular dendritic cells and intestinal epithelial cells none of which is capable of expressing IgE. The diverse nature of the expressing cells suggests that either the CD23-mediated signal transduction pathway may be different among the cell types or biological outcomes differ in different cells in response to the same signaling pathway. To address this issue, the CD23 signaling pathway was analyzed and compared in primary tonsillar B cells and in the monocytic cell lines U937 and THP-1. Activation of the tyrosine kinase Fyn and the serine/threonine kinase Akt were only observed in B cells. These results suggest that the CD23-mediated signal transduction pathways in human B cells and human monocytes are different. © 2010 Elsevier Inc.
ISSN: 15217035
Appears in Collections:Scopus 2006-2010

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