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Title: Characteristics of lymphocyte subsets in HIV-infected, long-term nonprogressor, and healthy Asian children through 12 years of age
Authors: Jintanat Ananworanich
Tanakorn Apornpong
Pope Kosalaraksa
Tanyathip Jaimulwong
Rawiwan Hansudewechakul
Chitsanu Pancharoen
Torsak Bunupuradah
Mom Chandara
Thanyawee Puthanakit
Chaiwat Ngampiyasakul
Jurai Wongsawat
Suparat Kanjanavanit
Wicharn Luesomboon
Phennapha Klangsinsirikul
Nicole Ngo-Giang-Huong
Stephen J. Kerr
Sasiwimol Ubolyam
Tawan Mengthaisong
Rebecca S. Gelman
Kovit Pattanapanyasat
Vonthanak Saphonn
Kiat Ruxrungtham
William T. Shearer
The HIV Netherlands Australia Thailand Research Collaboration
South East Asia Research Collaboration With Hawaii
Chulalongkorn University
Khon Kaen University
Chiangrai Prachanukroh Hospital
National Institute of Public Health
Prapokklao Hospital
Bamrasnaradura Infectious Diseases Institute
Nakornping Hospital
Queen Savang Vadhana Memorial Hospital
Chiang Mai University
IRD U174-Program for HIV Prevention and Treatment
National Center for HIV Epidemiology and Clinical Research
Harvard School of Public Health
Dana-Farber Cancer Institute
Mahidol University
National Center for HIV/AIDS
Baylor College of Medicine
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Dec-2010
Citation: Journal of Allergy and Clinical Immunology. Vol.126, No.6 (2010)
Abstract: Background: There are limited data on the immune profiles of HIV-positive children compared with healthy controls, and no such data for Asian children. Objectives: To immunophenotype HIV-positive Asian children, including long-term nonprogressors (LTNPs), compared with age-matched healthy controls. Methods: We used flow cytometry to analyze 13 lymphocyte and monocyte subsets from 222 untreated, HIV-positive children with 15% to 24% CD4+T cells and no AIDS-related illnesses and 142 healthy children (controls). Data were compared among age categories. Profiles from LTNPs (n = 50), defined as children ≥8 years old with CD4+T-cell counts ≥350 cells/mm3, were compared with data from age-matched non-LTNPs (n = 17) and controls (n = 53). Results: Compared with controls, HIV-positive children had lower values (cell count per mm3and percent distribution) for THcells and higher values for cytotoxic T cells, with reductions in populations of naive THand cytotoxic T cells, B cells, and natural killer (NK) cells. HIV-positive children had high values for activated THand cytotoxic T cells. Compared with non-LTNPs, LTNPs had higher values of THand cytotoxic T cells, naive and memory T-cell subsets, and B and NK cells. Surprisingly, counts of activated THand cytotoxic T cells were also higher among LTNPs. LNTPs were more frequently male. Conclusion: Untreated, HIV-infected Asian children have immune profiles that differ from those of controls, characterized by low values for THcells, naive T cells, B cells, and NK cells but high values for cytotoxic, activated TH, and cytotoxic T cells. The higher values for activated T cells observed in LTNPs require confirmation in longitudinal studies. © 2010 American Academy of Allergy, Asthma & Immunology.
ISSN: 00916749
Appears in Collections:Scopus 2006-2010

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