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dc.contributor.authorRie Takeuchien_US
dc.contributor.authorSaranath Lawpoolsrien_US
dc.contributor.authorMallika Imwongen_US
dc.contributor.authorJun Kobayashien_US
dc.contributor.authorJaranit Kaewkungwalen_US
dc.contributor.authorSasithon Pukrittayakameeen_US
dc.contributor.authorSupalap Puangsa-Arten_US
dc.contributor.authorNipon Thanyavanichen_US
dc.contributor.authorWanchai Maneeboonyangen_US
dc.contributor.authorNicholas Pj Dayen_US
dc.contributor.authorPratap Singhasivanonen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNational Center for Global Health and Medicineen_US
dc.date.accessioned2018-09-24T09:03:51Z-
dc.date.available2018-09-24T09:03:51Z-
dc.date.issued2010-11-03en_US
dc.identifier.citationMalaria Journal. Vol.9, No.1 (2010)en_US
dc.identifier.issn14752875en_US
dc.identifier.other2-s2.0-77958595486en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77958595486&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/29178-
dc.description.abstractBackground. Plasmodium vivax has a dormant hepatic stage, called the hypnozoite, which can cause relapse months after the initial attack. For 50 years, primaquine has been used as a hypnozoitocide to radically cure P. vivax infection, but major concerns remain regarding the side-effects of the drug and adherence to the 14-day regimen. This study examined the effectiveness of using the directly-observed therapy (DOT) method for the radical treatment of P. vivax malaria infection, to prevent reappearance of the parasite within the 90-day follow-up period. Other potential risk factors for the reappearance of P. vivax were also explored. Methods. A randomized trial was conducted from May 2007 to January 2009 in a low malaria transmission area along the Thai-Myanmar border. Patients aged 3 years diagnosed with P. vivax by microscopy, were recruited. All patients were treated with the national standard regimen of chloroquine for three days followed by primaquine for 14 days. Patients were randomized to receive DOT or self-administered therapy (SAT). All patients were followed for three months to check for any reappearance of P. vivax. Results. Of the 216 patients enrolled, 109 were randomized to DOT and 107 to SAT. All patients recovered without serious adverse effects. The vivax reappearance rate was significantly lower in the DOT group than the SAT group (3.4/10,000 person-days vs. 13.5/10,000 person-days, p = 0.021). Factors related to the reappearance of vivax malaria included inadequate total primaquine dosage received (< 2.75 mg/kg), duration of fever 2 days before initiation of treatment, parasite count on admission 10,000/νl, multiple P. vivax-genotype infection, and presence of P. falciparum infection during the follow-up period. Conclusions. Adherence to the 14-day primaquine regimen is important for the radical cure of P. vivax malaria infection. Implementation of DOT reduces the reappearance rate of the parasite, and may subsequently decrease P. vivax transmission in the area. © 2010 Takeuchi et al; licensee BioMed Central Ltd.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77958595486&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titleDirectly-observed therapy (DOT) for the radical 14-day primaquine treatment of Plasmodium vivax malaria on the Thai-Myanmar borderen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1186/1475-2875-9-308en_US
Appears in Collections:Scopus 2006-2010

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