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|Title:||A novel SR protein binding site in a cis-regulatory element of HIV-1|
|Keywords:||Immunology and Microbiology|
|Citation:||Archives of Virology. Vol.155, No.11 (2010), 1789-1795|
|Abstract:||We have previously described a cis enhancing sequence (CES) in the gp41 region of the HIV-1 env gene. It could enhance HIV-1 Gag expression via both rev-dependent and CTE (constitutive transport element)-dependent pathways. We identified a functionally important and conserved region in the CES that contained a predicted binding sequence for an SR protein, ASF/SF2. We show here that ASF/SF2 bound to this sequence in an electrophoretic mobility shift assay and that the putative ASF/SF2-binding sequence was required for the enhancement of Gag expression by CES and might play a role in HIV-1 posttranscriptional regulation. © 2010 Springer-Verlag.|
|Appears in Collections:||Scopus 2006-2010|
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