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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/29179
Title: A novel SR protein binding site in a cis-regulatory element of HIV-1
Authors: Ornpreya Suptawiwat
Chompunuch Boonarkart
Prasert Auewarakul
Mahidol University
Keywords: Immunology and Microbiology
Issue Date: 1-Nov-2010
Citation: Archives of Virology. Vol.155, No.11 (2010), 1789-1795
Abstract: We have previously described a cis enhancing sequence (CES) in the gp41 region of the HIV-1 env gene. It could enhance HIV-1 Gag expression via both rev-dependent and CTE (constitutive transport element)-dependent pathways. We identified a functionally important and conserved region in the CES that contained a predicted binding sequence for an SR protein, ASF/SF2. We show here that ASF/SF2 bound to this sequence in an electrophoretic mobility shift assay and that the putative ASF/SF2-binding sequence was required for the enhancement of Gag expression by CES and might play a role in HIV-1 posttranscriptional regulation. © 2010 Springer-Verlag.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78149411486&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/29179
ISSN: 03048608
Appears in Collections:Scopus 2006-2010

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