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Title: Pathogenicity of high-dose enteral inoculation of Burkholderia pseudomallei to mice
Authors: T. Eoin West
Nicolle D. Myers
Direk Limmathurotsakul
H. Denny Liggitt
Narisara Chantratita
Sharon J. Peacock
Shawn J. Skerrett
University of Washington School of Medicine
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Nov-2010
Citation: American Journal of Tropical Medicine and Hygiene. Vol.83, No.5 (2010), 1066-1069
Abstract: Melioidosis is a frequently lethal tropical infection caused by the environmental saprophyte Burkholderia pseudomallei. Although transcutaneous inoculation and inhalation are considered the primary routes of infection, suggestive clinical evidence implicates ingestion as a possible alternative route. We show that in BALB/c and C57BL/6 mice, direct gastric inoculation of high doses of B. pseudomallei causes systemic infection that may be lethal or cause chronic disseminated infection. Mice may shed bacteria in the stool for weeks after infection, and high titers of B. pseudomallei-specific IgG are detectable. This report of enteric murine melioidosis supports further consideration of this route of infection. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.
ISSN: 00029637
Appears in Collections:Scopus 2006-2010

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