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Title: Antiviral effect of PmRab7 knock-down on inhibition of Laem-Singh virus replication in black tiger shrimp
Authors: Chalermporn Ongvarrasopone
Ekapol Chomchay
Sakol Panyim
Mahidol University
Keywords: Immunology and Microbiology;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Oct-2010
Citation: Antiviral Research. Vol.88, No.1 (2010), 116-118
Abstract: PmRab7 is a Penaeus monodon small GTPase protein possibly involved in replication of several shrimp viruses. In this study RNA interference (RNAi) using double-stranded RNA (dsRNA) targeting PmRab7 gene (dsRNA-PmRab7) was employed to silence the expression of PmRab7 to investigate the inhibitory effect on Laem-Singh virus (LSNV) replication. Injection of dsRNA-PmRab7 24. h before challenge with the virus resulted in a drastic decrease of PmRab7 mRNA and complete inhibition of LSNV replication at 3 days post-challenge. In a therapeutic mode, shrimp injected with dsRNA-PmRab7 1 day but not at 3 or 5 days post-LSNV challenge resulted in inhibition of LSNV replication. These results pave the way to use dsRNA-PmRab7 to prevent or cure LSNV infection in shrimp. © 2010 Elsevier B.V.
ISSN: 18729096
Appears in Collections:Scopus 2006-2010

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