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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/29208
Title: Accuracy of rapid IgM-based immunochromatographic and immunoblot assays for diagnosis of acute scrub typhus and murine typhus infections in Laos
Authors: Stuart D. Blacksell
Kemajittra Jenjaroen
Rattanaphone Phetsouvanh
Ampai Tanganuchitcharnchai
Phonlavanh Phouminh
Simalee Phongmany
Nicholas P.J. Day
Paul N. Newton
Mahidol University
University of Oxford
Mahosot Hospital
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Aug-2010
Citation: American Journal of Tropical Medicine and Hygiene. Vol.83, No.2 (2010), 365-369
Abstract: We studied the diagnostic accuracy of a rapid immunochromatographic test (ICT) for detection of IgM against scrub typhus (ST ICT) and an immunoblot test for the detection of IgM against murine typhus (MT IBT) by using admission serum samples from 1,030 febrile patients in Laos. Sensitivity and specificity for the ST ICT determined by using the diagnostic criteria of a four-fold increase in IgM against Orientia tsutsugamushi between paired samples were 23.8% (95% confidence interval [CI] = 15.9-33.3%) and 86.2% (95% CI = 84.1-88.6%), respectively. Sensitivity and specificity for the ST ICT determined by using an admission IgM titer ≥ 1:400 were 39.1% (95% CI = 34.1-44.2%) and 99.5% (95% CI = 98,7-99.9%), respectively. Sensitivity and specificity for the MT IBT determined by using the criteria of a four-fold increase in IgM against Rickettsia typhi between paired serum samples were 61.2% (95% CI = 53.7-68.3%) and 86.5% (95% CI = 84.1-88.8%), respectively. Sensitivity and specificity for the MT IBT determined by using an admission IgM titer ≥ 1:400 were 54.6% (95% CI = 49.1-60.0%) and 94.1 % (95% CI = 92.0-95.7%). respectively. Both assays had relatively good specificity but low sensitivity and thus have limited utility for admission diagnosis. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77955593341&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/29208
ISSN: 00029637
Appears in Collections:Scopus 2006-2010

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