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dc.contributor.authorBounkong Syhavongen_US
dc.contributor.authorBouachanh Rasachacken_US
dc.contributor.authorLee Smytheen_US
dc.contributor.authorJean Marc Rolainen_US
dc.contributor.authorAnne Marie Roque-Afonsoen_US
dc.contributor.authorKemajittra Jenjaroenen_US
dc.contributor.authorVimone Soukkhasermen_US
dc.contributor.authorSimmaly Phongmanyen_US
dc.contributor.authorRattanaphone Phetsouvanhen_US
dc.contributor.authorSune Soukkhasermen_US
dc.contributor.authorTe Thammavongen_US
dc.contributor.authorMayfong Mayxayen_US
dc.contributor.authorStuart D. Blacksellen_US
dc.contributor.authorEleanor Barnesen_US
dc.contributor.authorPhilippe Parolaen_US
dc.contributor.authorElisabeth Dussaixen_US
dc.contributor.authorDidier Raoulten_US
dc.contributor.authorIsla Humphreysen_US
dc.contributor.authorPaul Klenermanen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.authorPaul N. Newtonen_US
dc.contributor.otherMahosot Hospitalen_US
dc.contributor.otherQueensland Healthen_US
dc.contributor.otherFaculte de Medecine de Marseille Universite de la Mediterraneeen_US
dc.contributor.otherHopital Paul-Brousseen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Oxforden_US
dc.contributor.otherNational Blood Transfusion Centreen_US
dc.contributor.otherUniversity of Health Sciencesen_US
dc.identifier.citationTransactions of the Royal Society of Tropical Medicine and Hygiene. Vol.104, No.7 (2010), 475-483en_US
dc.description.abstractThere is little information on the diverse infectious causes of jaundice and hepatitis in the Asiatic tropics. Serology (hepatitis A, B, C and E, leptospirosis, dengue, rickettsia), antigen tests (dengue), PCR assays (hepatitis A, C and E) and blood cultures (septicaemia) were performed on samples from 392 patients admitted with jaundice or raised transaminases (≥×3) to Mahosot Hospital, Vientiane, Laos over 3 years. Conservative definitions suggested diagnoses of dengue (8.4%), rickettsioses (7.3%), leptospirosis (6.8%), hepatitis B (4.9%), hepatitis C (4.9%), community-acquired septicaemia (3.3%) and hepatitis E (1.6%). Although anti-hepatitis A virus (HAV) IgM antibody results suggested that 35.8% of patients had acute HAV infections, anti-HAV IgG antibody avidity and HAV PCR suggested that 82% had polyclonal activation and not acute HAV infections. Scrub typhus, murine typhus or leptospirosis were present in 12.8% of patients and were associated with meningism and relatively low AST and ALT elevation. These patients would be expected to respond to empirical doxycycline therapy which, in the absence of virological diagnosis and treatment, may be an appropriate cost-effective intervention in Lao patients with jaundice/hepatitis. © 2010 Royal Society of Tropical Medicine and Hygiene.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleThe infective causes of hepatitis and jaundice amongst hospitalised patients in Vientiane, Laosen_US
Appears in Collections:Scopus 2006-2010

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