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Title: Comparative identification of protein profiles and major allergens of saliva, salivary gland and whole body extracts of mosquito species in Thailand
Authors: Sirichit Wongkamchai
Pacharee Khongtak
Somjai Leemingsawat
Narumon Komalamisra
Nujorn Junsong
Kanokvalai Kulthanan
Wanee Wisuthsarewong
John J. Boitano
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jun-2010
Citation: Asian Pacific Journal of Allergy and Immunology. Vol.28, No.2-3 (2010), 162-169
Abstract: Allergic reactions to mosquito bites, such as generalized urticaria or severe local reactions are common problems worldwide. The diverse sources of allergen prepared from different mosquito body parts usage are a major obstacle to obtaining safe and effective tests and immunotherapy for mosquito bite allergy. Thus, the reactions are often not recognized and allergen immunotherapy is seldom used for severe reaction to mosquito bites. In a search for appropriate allergen sources, the protein profiles of saliva, salivary glands and whole body extracts were comparatively analyzed from 4 common mosquito species of Thailand and/or South East Asia; viz. Culex quinquefasciatus, Aedes aegypti, Aedes albopictus and a zoophilic strain, Anopheles minimus. The major allergens in the extracts which elicited specific IgE responses in the pooled sera of subjects allergic to mosquito bites were identified. It was concluded that mosquito saliva was the best source of allergens. Additionally, both species-specific and species-shared allergens of the 4 mosquito species were identified. The major saliva allergens having MWs of 36, 32 and 22 kDa were identified. The identificstion of major allergens should facilitate the production of specific recombinant allergens and contribute to improvement in the diagnosis and specific immunotherapy of Thai mosquito bite allergy patients.
ISSN: 0125877X
Appears in Collections:Scopus 2006-2010

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