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Title: A combination of intravenous immunoglobulin and pulse methylprednisolone extended survival in pulmonary alveolar proteinosis with chronic interstitial pneumonitis: A case report
Authors: Nongnapa Jirarattanasopa
Chutsumarn Tantikul
Pakit Vichyanond
Punchama Pacharn
Nualanong Visitsunthorn
Panthep Suttinont
Orathai Jirapongsananuruk
Division of Allergy and Immunology
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jun-2010
Citation: Asian Pacific Journal of Allergy and Immunology. Vol.28, No.2-3 (2010), 200-205
Abstract: Pulmonary alveolar proteinosis (PAP) is characterized by intra-alveolar accumulation of lipoproteinaceous material. The severe chronic pulmonary disease and susceptibility to pulmonary infection is a prominent feature of the disease. We reported a case of postnatal-onset PAP and chronic interstitial pneumonitis in a girl with chronic respiratory distress since she was 5 months of age. A lung biopsy confirmed the diagnosis. The therapeutic bronchoalveolar lavages, a short trial of granulocyte colonystimulation factor (G-CSF) and a combination of low dose methylprednisolone and hydroxychloroquine were used at different times without noting satisfactory improvement. Intravenous immunoglobulin (IVIG) and pulse methylprednisolone were given monthly with gradual recovery. She did not require oxygen supplement after 21 months of this combination. Our report suggested that IVIG and pulse methylprednisolone might have a potential role in the treatment of PAP with chronic interstitial pneumonitis.
ISSN: 0125877X
Appears in Collections:Scopus 2006-2010

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