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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/29226
Title: Monophyly of Opisthorchis viverrini populations in the lower Mekong Basin, using mitochondrial DNA nad1 gene as the marker
Authors: Urusa Thaenkham
Supaporn Nuamtanong
Surapol Sa-nguankiat
Tippayarat Yoonuan
Sarun Touch
Khemphavanh Manivong
Youthanavanh Vonghachack
Megumi Sato
Jitra Waikagul
Mahidol University
AIDS
Malaria Station
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jun-2010
Citation: Parasitology International. Vol.59, No.2 (2010), 242-247
Abstract: The liver fluke, Opisthorchis viverrini, causes serious public-health problems in the Lower Mekong Basin. This study aimed to clarify whether O. viverrini populations may be genetically divided into sub-specific taxa. We collected 6 populations of O. viverrini from different places in Cambodia, Lao PDR, and Thailand, along both sides of the Mekong River, and analyzed the population structure of these using the mitochondrial nad1 gene as a marker. The results of the DNA polymorphism measurements, by theta-w (θw) and -π (θπ) values, neutrality tests, and mismatch distribution, suggested that the population of O. viverrini has expanded under the influence of purifying selection and selective sweep. The analysis of molecular variance (AMOVA) test revealed no significant genetic differences among the O. viverrini populations on opposite sides of the Mekong River. O. viverrini haplotypes occurred in multiple populations, and no distinct geographical clade. The star-like haplotype network confirmed a demographic expansion of the O. viverrini population. Overall, the genetic data from these populations suggested that the postulated existence of an O. viverrini species complex should be rejected. The bio-geographical diversity of O. viverrini populations should be explored further, using other appropriate markers and a wider range of samples from geographically different areas. © 2010 Elsevier Ireland Ltd. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77951666544&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/29226
ISSN: 13835769
Appears in Collections:Scopus 2006-2010

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