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dc.contributor.authorUrusa Thaenkhamen_US
dc.contributor.authorSupaporn Nuamtanongen_US
dc.contributor.authorSurapol Sa-nguankiaten_US
dc.contributor.authorTippayarat Yoonuanen_US
dc.contributor.authorSarun Touchen_US
dc.contributor.authorKhemphavanh Manivongen_US
dc.contributor.authorYouthanavanh Vonghachacken_US
dc.contributor.authorMegumi Satoen_US
dc.contributor.authorJitra Waikagulen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherMalaria Stationen_US
dc.identifier.citationParasitology International. Vol.59, No.2 (2010), 242-247en_US
dc.description.abstractThe liver fluke, Opisthorchis viverrini, causes serious public-health problems in the Lower Mekong Basin. This study aimed to clarify whether O. viverrini populations may be genetically divided into sub-specific taxa. We collected 6 populations of O. viverrini from different places in Cambodia, Lao PDR, and Thailand, along both sides of the Mekong River, and analyzed the population structure of these using the mitochondrial nad1 gene as a marker. The results of the DNA polymorphism measurements, by theta-w (θw) and -π (θπ) values, neutrality tests, and mismatch distribution, suggested that the population of O. viverrini has expanded under the influence of purifying selection and selective sweep. The analysis of molecular variance (AMOVA) test revealed no significant genetic differences among the O. viverrini populations on opposite sides of the Mekong River. O. viverrini haplotypes occurred in multiple populations, and no distinct geographical clade. The star-like haplotype network confirmed a demographic expansion of the O. viverrini population. Overall, the genetic data from these populations suggested that the postulated existence of an O. viverrini species complex should be rejected. The bio-geographical diversity of O. viverrini populations should be explored further, using other appropriate markers and a wider range of samples from geographically different areas. © 2010 Elsevier Ireland Ltd. All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleMonophyly of Opisthorchis viverrini populations in the lower Mekong Basin, using mitochondrial DNA nad1 gene as the markeren_US
Appears in Collections:Scopus 2006-2010

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