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Title: Review: Diagnosis of scrub typhus
Authors: Gavin C.K.W. Koh
Richard J. Maude
Daniel H. Paris
Paul N. Newton
Stuart D. Blacksell
Mahidol University
Academic Medical Centre, University of Amsterdam
University of Cambridge
Mahosot Hospital
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Mar-2010
Citation: American Journal of Tropical Medicine and Hygiene. Vol.82, No.3 (2010), 368-370
Abstract: Scrub typhus is transmitted by trombiculid mites and is endemic to East and Southeast Asia and Northern Australia. The clinical syndrome classically consists of a fever, rash, and eschar, but scrub typhus also commonly presents as an undifferentiated fever that requires laboratory confirmation of the diagnosis, usually by indirect fluorescent antibody (IFA) assay. We discuss the limitations of IFA, debate the value of other methods based on antigen detection and nucleic acid amplification, and outline recommendations for future study. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.
ISSN: 00029637
Appears in Collections:Scopus 2006-2010

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