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Title: Artemisinin resistance: Current status and scenarios for containment
Authors: Arjen M. Dondorp
Shunmay Yeung
Lisa White
Chea Nguon
Nicholas P.J. Day
Duong Socheat
Lorenz Von Seidlein
Mahidol University
University of Oxford
London School of Hygiene & Tropical Medicine
National Center for Parasitology Entomology and Malaria Control
Joint Malaria Programme
Keywords: Immunology and Microbiology
Issue Date: 1-Jan-2010
Citation: Nature Reviews Microbiology. Vol.8, No.4 (2010), 272-280
Abstract: Artemisinin combination therapies are the first-line treatments for uncomplicated Plasmodium falciparum malaria in most malaria-endemic countries. Recently, partial artemisinin-resistant P. falciparum malaria has emerged on the Cambodiaĝ€"Thailand border. Exposure of the parasite population to artemisinin monotherapies in subtherapeutic doses for over 30 years, and the availability of substandard artemisinins, have probably been the main driving force in the selection of the resistant phenotype in the region. A multifaceted containment programme has recently been launched, including early diagnosis and appropriate treatment, decreasing drug pressure, optimising vector control, targeting the mobile population, strengthening management and surveillance systems, and operational research. Mathematical modelling can be a useful tool to evaluate possible strategies for containment. © 2010 Macmillan Publishers Limited. All rights reserved.
ISSN: 17401526
Appears in Collections:Scopus 2006-2010

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