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Title: Acute dengue virus 2 infection in Gabonese patients is associated with an early innate immune response, including strong interferon alpha production
Authors: Pierre Becquart
Nadia Wauquier
Dieudonné Nkoghe
Angélique Ndjoyi-Mbiguino
Cindy Padilla
Marc Souris
Eric M. Leroy
Centre International de Recherches Medicales de Franceville
Maladies Infectieuses et Vecteurs : Ecologie, Genetique, Evolution et Controle
Université des Sciences de la Santé
Emergence des Pathologies Virales
Mahidol University
Keywords: Medicine
Issue Date: 17-Dec-2010
Citation: BMC Infectious Diseases. Vol.10, (2010)
Abstract: Background: Dengue is now a leading cause of morbidity and mortality throughout the tropics. We conducted the first ex vivo study of dengue fever (DF) in African patients infected during the first Gabonese dengue virus 2 (DENV-2) outbreak in 2007, in order to investigate cytokine production, including the antiviral cytokine IFN-α, reported to be a potent inhibitor of DENV replication in vitro.Methods: Levels of 50 cytokines, chemokines and growth factors were measured in plasma from 36 patients with DENV-2 infection, and in uninfected controls, using Luminex multiplex technology. The results were interpreted according to the day of sampling after symptom onset. PBMC from six patients were also studied for T lymphocyte cell surface marker expression by flow cytometry.Results: Acute DENV-2 infection elicited high levels of several pro-inflammatory cytokines (IL-6 and IL-17), chemokines (MIF, RANTES, IP-10 and MCP-1) and growth factors (G-CSF, GM-CSF and VEGF-A). We also observed high levels of IFN-α for the first time in adult DF patients, and CD4+ and CD8+ T cell activation at symptom onset.Conclusion: Acute DENV-2 infection in African patients elicits a strong innate response involving IFN-α production, as well as an adaptive immune response. © 2010 Becquart et al; licensee BioMed Central Ltd.
ISSN: 14712334
Appears in Collections:Scopus 2006-2010

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