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Title: A retrospective study of multiple sclerosis in Thailand
Authors: Sasitorn Siritho
Naraporn Prayoonwiwat
Teeratorn Pulkes
Siwaporn Chankrachang
Somsak Laptikultham
Samart Nidhinandana
Suwanna Sethawacharawanit
Tasanee Tantirittisak
Arkhom Arayawichanont
Mahidol University
Faculty of Medicine Chiang Mai University
Rajvithee Hospital
Pramongkutklao Hospital
Prince of Songkla University
Prasat Neurological Institute
Sappasitthiprasong Hospital
Keywords: Medicine;Neuroscience
Issue Date: 1-Dec-2010
Citation: Neurology Asia. Vol.15, No.3 (2010), 253-261
Abstract: Objectives: To determine the prevalence of Thai demyelinating diseases regarding demographic data, symptoms and signs, associated diseases, disease progression, cerebrospinal fluid analysis and imaging findings. Methods: A multicenter retrospective study of 107 MS patients attending the Neurological Centers in Thailand during June and December 2004 was performed. Each had an initial diagnosis of demyelinating diseases. Results: From 107 patients, there were 78.5% female and 21.5% male with the female: male ratio of 3.7:1. The age at onset was 32.7±11.5 years. The mean disease duration was 3.8±5.1 years and the mean number of relapses was 4.6±4.4 with annual relapse rate of 1.5±1.3 times. None reported a family history of MS. Recurrent optico-spinal form was 27.1% followed by 17.8% of spinal form and 15% of western form of MS. The most common presenting symptom was visual impairment (51.4%). Only 24.1% demonstrated oligoclonal bands in CSF. The median score of EDSS at their latest visits was 3.0 with mean score of 3.8±3.0. Conclusions: MS in Thailand is different from Western countries. There were no occurrence of MS in families, higher incidence of visual impairment at onset, more common recurrent optico-spinal form and lower incidence of oligoclonal bands in the CSF.
ISSN: 18236138
Appears in Collections:Scopus 2006-2010

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