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Title: In vitro activity of doripenem and other carbapenems against contemporary Gram-negative pathogens isolated from hospitalised patients in the Asia-Pacific region: Results of the COMPACT Asia-Pacific Study
Authors: K. J. Christiansen
M. Ip
H. B. Ker
M. Mendoza
L. Hsu
P. Kiratisin
A. Chongthaleong
I. S. Redjeki
A. Quintana
R. Flamm
J. Garcia
M. Cassettari
D. Cooper
P. Okolo
I. Morrissey
Royal Perth Hospital
Chinese University of Hong Kong
Hospital Raja Permaisuri Bainun
Philippine General Hospital
National University Hospital, Singapore
Mahidol University
King Chulalongkorn Memorial Hospital, Faculty of Medicine Chulalongkorn University
Hasan Sadikin General Hospital
Johnson & Johnson
Janssen-Cilag Asia-Pacific
Pharmaron UK
Keywords: Medicine
Issue Date: 1-Dec-2010
Citation: International Journal of Antimicrobial Agents. Vol.36, No.6 (2010), 501-506
Abstract: The Comparative Activity of Carbapenems Testing (COMPACT) Study was designed to determine the in vitro potency of doripenem compared with imipenem and meropenem against a large number of contemporary Gram-negative pathogens from more than 100 centres across Europe and the Asia-Pacific region and to assess the reliability of Etest methodology for doripenem minimum inhibitory concentration (MIC) determination against these pathogens. Data from eight countries within the Asia-Pacific region, which collected 1612 bacterial isolates, are presented here. Etest methodology was found to be a reliable method for MIC determination. Doripenem showed in vitro activity similar to or better than meropenem and at least four-fold better than imipenem against Enterobacteriaceae. Against Pseudomonas aeruginosa, doripenem was also the most active of the three carbapenems in vitro. However, in vitro results do not necessarily correlate with clinical outcome. © 2010 Elsevier B.V. and the International Society of Chemotherapy.
ISSN: 09248579
Appears in Collections:Scopus 2006-2010

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