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Title: Antiretroviral therapy outcomes of HIV-infected children in the TREAT Asia pediatric HIV observational database
Authors: Rawiwan Hansudewechakul
Virat Sirisanthana
Nia Kurniati
Thanyawee Puthanakit
Pagakrong Lumbiganon
Vonthanak Saphonn
Nik Khairulddin Nik Yusoff
Nagalingeswaran Kumarasamy
Siew Moy Fong
Revathy Nallusamy
Preeyaporn Srasuebkul
Matthew Law
Annette H. Sohn
Kulkanya Chokephaibulkit
Chiangrai Prachanukroh Hospital
Chiang Mai University
University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
The HIV Netherlands Australia Thailand Research Collaboration
Khon Kaen University
National Center for HIV/AIDS
Hospital Raja Perempuan Zainab II
YR Gaitonde Centre for AIDS Research and Education
Hospital Likas
Penang Adventist Hospital
Kirby Institute
TREAT Asia/amfAR-The Foundation for AIDS Research
Mahidol University
Keywords: Medicine
Issue Date: 1-Dec-2010
Citation: Journal of Acquired Immune Deficiency Syndromes. Vol.55, No.4 (2010), 503-509
Abstract: Introduction: We report responses to combination antiretroviral therapy (cART) in the Therapeutics Research, Education, and AIDS Training in Asia Pediatric HIV Observational Database. Methods: Children included were those who had received cART (ie, ≥3 antiretrovirals) at <18 years. The analysis was intention-to-treat by the first cART regimen. Median values are provided with interquartile ranges; hazard ratios (HRs) with 95% confidence intervals. Results: Of the 1655 children included, 50.4% were male, with a median age at cART of 7.0 (3.9-9.8) years and CD4 of 8% (2.0%-15%); 92.5% were started on an NNRTI; median duration of follow-up was 2.9 (1.4-4.6) years. Loss-to-follow-up and death rates were 4.2 (3.7-4.8) and 2.1 (1.7-2.5) per 100 person-years, respectively. At 36 months, median CD4 was 26% (21%-31%); 81% of those with viral load (n = 302) were <400 copies per milliliter. Children who reached CD4 ≥25% within 5 years were more likely to be females (HR: 1.4; 1.2-1.7), start before 18 months old (HR: 3.8; 2.4-6.2), lack a history of monotherapy/dual therapy (HR: 1.7; 1.4-2.5), and have a higher baseline CD4 (per 10% increase: HR: 2; 1.9-2.2). Conclusions: These data underscore the need for early diagnosis and cART initiation to preserve immune function. © 2010 Lippincott Williams & Wilkins.
ISSN: 15254135
Appears in Collections:Scopus 2006-2010

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