Please use this identifier to cite or link to this item:
Title: Cryptococcal immune reconstitution inflammatory syndrome in HIV-1-infected individuals: proposed clinical case definitions
Authors: Lewis J. Haddow
Robert Colebunders
Graeme Meintjes
Stephen D. Lawn
Julian H. Elliott
Yukari C. Manabe
Paul R. Bohjanen
Somnuek Sungkanuparph
Philippa J. Easterbrook
Martyn A. French
David R. Boulware
King's College London
The Nelson R. Mandela Medical School
Prins Leopold Instituut voor Tropische Geneeskunde
Universiteit Antwerpen
University of Cape Town
London School of Hygiene & Tropical Medicine
University of Cape Town, Faculty of Health Sciences
Alfred Hospital
Macfarlane Burnet Institute for Medical Research
Makerere University
The Johns Hopkins School of Medicine
University of Minnesota Twin Cities
Mahidol University
University of Western Australia
Royal Perth Hospital
Keywords: Medicine
Issue Date: 1-Nov-2010
Citation: The Lancet Infectious Diseases. Vol.10, No.11 (2010), 791-802
Abstract: Cryptococcal immune reconstitution inflammatory syndrome (IRIS) may present as a clinical worsening or new presentation of cryptococcal disease after initiation of antiretroviral therapy (ART), and is thought to be caused by recovery of cryptococcus-specific immune responses. We have reviewed reports of cryptococcal IRIS and have developed a consensus case definition specifically for paradoxical crytopcoccal IRIS in patients with HIV-1 and known cryptococcal disease before ART, and a separate definition for incident cryptococcosis developed during ART (termed ART-associated cryptococcosis), for which a proportion of cases are likely to be unmasking cryptococcal IRIS. These structured case definitions are intended to aid design of future clinical, epidemiological, and immunopathological studies of cryptococcal IRIS, to standardise diagnostic criteria, and to facilitate comparisons between studies. As for definitions of tuberculosis-associated IRIS, definitions for cryptococcal IRIS should be regarded as preliminary until further insights into the immunopathology of IRIS permit their refinement. © 2010 Elsevier Ltd.
ISSN: 14733099
Appears in Collections:Scopus 2006-2010

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.