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Title: Changes in platelet count in uncomplicated and severe falciparum Malaria
Authors: Wattana Leowattana
Noppadon Tangpukdee
Sai Kaung Thar
Souwanit Nakasiri
Siripun Srivilairit
Shigeyuki Kano
Polrat Wilairatana
Srivicha Krudsood
Mahidol University
National Center for Global Health and Medicine
Keywords: Medicine
Issue Date: 1-Sep-2010
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.41, No.5 (2010), 1035-1041
Abstract: This study investigated alterations in platelet counts pre- and post-treatment with artemisinin derivatives in uncomplicated and severe falciparum malaria. Serial platelet counts were taken over 4 weeks for 110 uncomplicated and 110 severe falciparum malaria patients admitted to the Hospital for Tropical Diseases during 2005-2008. On admission, prior to treatment, thrombocytopenia was found in 73.6% of uncomplicated falciparum malaria patients and 90.9% of severe falciparum malaria cases. Platelet levels significantly lower in severe malaria cases. Although initial platelet counts were lower than normal in both study groups, they slowly increased significantly over time, and approached normal levels by several weeks post-treatment. No bleeding was evident during treatment, and none of the patients required a platelet transfusion. Platelet transfusions are not required for malaria patients with thrombocytopenia who have no bleeding.
ISSN: 01251562
Appears in Collections:Scopus 2006-2010

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