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Title: International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers
Authors: Paul Kirk
Taigang He
Lisa J. Anderson
Michael Roughton
Mark A. Tanner
Wynnie W.M. Lam
Wing Y. Au
Winnie C.W. Chu
Godfrey Chan
Renzo Galanello
Gildo Matta
Mark Fogel
Alan R. Cohen
Ru San Tan
Kevin Chen
Ivy Ng
Angie Lai
Suthat Fucharoen
Jiraporn Laothamata
Suporn Chuncharunee
Sutipong Jongjirasiri
David N. Firmin
Gillian C. Smith
Dudley J. Pennell
Royal Brompton Hospital
Chinese University of Hong Kong
The University of Hong Kong
Azienda Ospedaliera Brotzu - Microcitemico
Azienda Ospedaliera Brotzu
The Children's Hospital of Philadelphia
National Heart Centre, Singapore
Singapore General Hospital
KK Women's And Children's Hospital
Mahidol University
Keywords: Medicine
Issue Date: 1-Aug-2010
Citation: Journal of Magnetic Resonance Imaging. Vol.32, No.2 (2010), 315-319
Abstract: Purpose: To examine the reproducibility of the single breathhold T2* technique fromdifferent scanners, after installation of standardmethodology in five international centers. Materials and Methods: Up to 10 patients from each center were scanned twice locally for local interstudy reproducibility of heart and liver T2*, and then flown to a central MR facility to be rescanned on a reference scanner for intercenter reproducibility. Interobserver reproducibility for all scans was also assessed. Results: Of the 49 patients scanned, the intercenter reproducibility for T2* was 5.9% for the heart and 5.8% for the liver. Local interstudy reproducibility for T2* was 7.4% for the heart and 4.6% for the liver. Interobserver reproducibility for T2* was 5.4% for the heart and 4.4% for the liver. Conclusion: These data indicate that T2* MR may be developed into a widespread test for tissue siderosis providing that well-defined and approved imaging and analysis techniques are used. © 2010 Wiley-Liss, Inc.
ISSN: 15222586
Appears in Collections:Scopus 2006-2010

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