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Title: Transcriptional profiling of Clostridium difficile and Caco-2 cells during infection
Authors: Tavan Janvilisri
Joy Scaria
Yung Fu Chang
Cornell University
Mahidol University
Keywords: Medicine
Issue Date: 15-Jul-2010
Citation: Journal of Infectious Diseases. Vol.202, No.2 (2010), 282-290
Abstract: Clostridium difficile is well recognized as the most common infectious cause of nosocomial diarrhea. The incidence and severity of C. difficile infection (CDI) is increasing worldwide. Here, we evaluated simultaneously the transcriptional changes in the human colorectal epithelial Caco-2 cells and in C. difficile after infection. A total of 271 transcripts in Caco-2 cells and 207 transcripts in C. difficile were significantly differentially expressed at ≥1 time point during CDI. We used the gene ontology annotations and protein-protein network interactions to underline a framework of target molecules that could potentially play a key role during CDI. These genes included those associated with cellular metabolism, transcription, transport, cell communication, and signal transduction. Our data identified certain key factors that have previously been reported to be involved in CDI, as well as novel determinants that may participate in a complex mechanism underlying the host response to infection, bacterial adaptation, and pathogenesis. © 2010 by the Infectious Diseases Society of America. All rights reserved.
ISSN: 00221899
Appears in Collections:Scopus 2006-2010

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