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Title: Two nonrecombining sympatric forms of the human malaria parasite plasmodium ovale occur globally
Authors: Colin J. Sutherland
Naowarat Tanomsing
Debbie Nolder
Mary Oguike
Charlie Jennison
Sasithon Pukrittayakamee
Christiane Dolecek
Tran Tinh Hien
Virgilio E. Do Rosário
Ana Paula Arez
João Pinto
Pascal Michon
Ananias A. Escalante
Francois Nosten
Martina Burke
Rogan Lee
Marie Blaze
Thomas Dan Otto
John W. Barnwell
Arnab Pain
John Williams
Nicholas J. White
Nicholas P.J. Day
Georges Snounou
Peter J. Lockhart
Peter L. Chiodini
Mallika Imwong
Spencer D. Polley
Health Protection Agency
London School of Hygiene & Tropical Medicine
Churchill Hospital
Sanger Genome Centre
Mahidol University
Royal Institute
Shoklo Malaria Research Unit
University of Oxford
Universidade Nova de Lisboa, Instituto de Higiene e Medicina Tropical
Papua New Guinea Institute of Medical Research
Arizona State University
Centers for Disease Control and Prevention
Westmead Hospital
Faculte de Medecine Pierre et Marie Curie
National University of Singapore
Massey University
Keywords: Medicine
Issue Date: 15-May-2010
Citation: Journal of Infectious Diseases. Vol.201, No.10 (2010), 1544-1550
Abstract: Background. Malaria in humans is caused by apicomplexan parasites belonging to 5 species of the genus Plasmodium. Infections with Plasmodium ovale are widely distributed but rarely investigated, and the resulting burden of disease is not known. Dimorphism in defined genes has led to P ovale parasites being divided into classic and variant types. We hypothesized that these dimorphs represent distinct parasite species. Methods. Multilocus sequence analysis of 6 genetic characters was carried out among 55 isolates from 12 African and 3 Asia-Pacific countries. Results. Each genetic character displayed complete dimorphism and segregated perfectly between the 2 types. Both types were identified in samples from Ghana, Nigeria, São Tomé, Sierra Leone, and Uganda and have been described previously in Myanmar. Splitting of the 2 lineages is estimated to have occurred between 1.0 and 3.5 million years ago in hominid hosts. Conclusions. We propose that P ovale comprises 2 nonrecombining species that are sympatric in Africa and Asia. We speculate on possible scenarios that could have led to this speciation. Furthermore, the relatively high frequency of imported cases of symptomatic P ovale infection in the United Kingdom suggests that the morbidity caused by ovale malaria has been underestimated. © 2010 by the Infectious Diseases Society of America. All rights reserved.
ISSN: 00221899
Appears in Collections:Scopus 2006-2010

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