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Title: Cross-reacting antibodies enhance dengue virus infection in humans
Authors: Wanwisa Dejnirattisai
Amonrat Jumnainsong
Naruthai Onsirisakul
Patricia Fitton
Sirijitt Vasanawathana
Wannee Limpitikul
Chunya Puttikhunt
Carolyn Edwards
Thaneeya Duangchinda
Sunpetchuda Supasa
Kriangkrai Chawansuntati
Prida Malasit
Juthathip Mongkolsapaya
Gavin Screaton
Imperial College London
Mahidol University
Khon Kaen Regional Hospital
Songkhla Hospital
Thailand National Center for Genetic Engineering and Biotechnology
Keywords: Medicine;Multidisciplinary
Issue Date: 7-May-2010
Citation: Science. Vol.328, No.5979 (2010), 745-748
Abstract: Dengue virus co-circulates as four serotypes, and sequential infections with more than one serotype are common. One hypothesis for the increased severity seen in secondary infections is antibodydependent enhancement (ADE) leading to increased replication in Fc receptor-bearing cells. In this study, we have generated a panel of human monoclonal antibodies to dengue virus. Antibodies to the structural precursor-membrane protein (prM) form a major component of the response. These antibodies are highly cross-reactive among the dengue virus serotypes and, even at high concentrations, do not neutralize infection but potently promote ADE. We propose that the partial cleavage of prM from the viral surface reduces the density of antigen available for viral neutralization, leaving dengue viruses susceptible to ADE by antibody to prM, a finding that has implications for future vaccine design.
ISSN: 10959203
Appears in Collections:Scopus 2006-2010

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