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Title: High prevalence of CTX-M β-lactamase-producing enterobacteriaceae in stool specimens obtained from healthy individuals in Thailand
Authors: Tadahiro Sasaki
Itaru Hirai
Marie Niki
Tatsuya Nakamura
Chalit Komalamisra
Wanna Maipanich
Teera Kusolsuk
Surapol Sa-nguankiat
Somchit Pubampen
Yoshimasa Yamamoto
Osaka University Faculty of Medicine
Kobe University School of Medicine
Kansai Medical University
Mahidol University
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 27-Jan-2010
Citation: Journal of Antimicrobial Chemotherapy. Vol.65, No.4 (2010), 666-668
Abstract: Objectives: To determine the prevalence of CTX-M β-lactamase-producing Enterobacteriaceae in stool specimens obtained from healthy individuals in a rural area of Thailand. Methods: Bacteria in stool specimens were screened for extended-spectrum β-lactamase (ESBL) production on McConkey agar with cefotaxime and confirmed by the double-disc synergy test. Genetic detection and genotyping of CTX-M-type ESBL was performed by PCR with bacterial DNA extracted from isolates. Results: A markedly high number (82 of 141, 58.2%) of the specimens showed the presence of CTX-M β-lactamase-producing Enterobacteriaceae, as confirmed by both phenotypic and genetic examinations. The majority of the CTX-M β-lactamase-producing bacteria were Escherichia coli (85.1%). Conclusions: The study revealed the wide dissemination of CTX-M β-lactamase-producing Enterobacteriaceae in the healthy population. © The Author 2010. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy.
ISSN: 14602091
Appears in Collections:Scopus 2006-2010

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